Investigation into the Use of Short-Column Reversed-Phase LC in the Determination of log P Values

Aim To investigate the possibility of determining log P via Reversed-Phase LC
Introduction
Increasingly, the determination of low concentrations of active ingredients in complex mixtures, sold for human consumption, has become more necessary. Regulations have imposed strict limits on the type and concentrations of a host of substances sold as foods or drugs. Such requirements demand analytical techniques that are fast and reliable and combine the separation and analysis steps in a single operation. Chromatography is the most widely used technique for the analysis of non-inorganic mixtures…