Muscle Atrophy with Age: Explore the mechanisms behind muscle atrophy in elderly populations, including changes in muscle fibers and motor units

This review article provides a broad overview of the mechanisms behind muscle atrophy with age, focusing on changes in muscle fibers and motor units. The study highlights the multifaceted nature of muscle atrophy, influenced by various factors such as changes in muscle fibers, motor units, and signaling pathways. The results indicate that muscle atrophy in older adults is characterized by a reduction in satellite cell content, particularly in type II skeletal muscle fibers crucial for power and strength. Additionally, the decline in growth factor signals and mechanical unloading, such as prolonged periods of inactivity or immobilization, can contribute to muscle loss in older adults. The study emphasizes the importance of maintaining physical activity throughout life to preserve muscle health and function. Furthermore, it discusses potential interventions to counteract muscle atrophy, including nutritional strategies and caloric restriction. The review aims to provide a thorough understanding of the complex processes involved in muscle atrophy with age, highlighting the need for a combinational approach to address this public health concern.…